5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

Base Information

Chemical Name:5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline
CAS No.:1084331-65-6
Molecular Formula:C₁₉H₂₀F₂IN₃O₃
Molecular Weight:503.287
Hs Code.:

Synonyms:5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

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Chemical Property of 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

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Technology Process of 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

There total 4 articles about 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1084333-28-7
tert-butyl 4-(2-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}ethyl)piperidine-1-carboxylate

: 1084331-65-6
5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

Guidance literature:: tert-butyl 4-(2-{5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-2-nitrophenoxy}ethyl)piperidine-1-carboxylate; With hydrogenchloride; In water; acetonitrile; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1084331-65-6
5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h

1.2: 0.5 h

2.1: sodium hydride / N,N-dimethyl-formamide / 20 - 90 °C

2.2: 0.5 h

3.1: hydrogenchloride / water; acetonitrile / 1 h / 20 °C

With hydrogenchloride; potassium tert-butylate; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 765962-75-2
3,5-difluoro-N-(2-fluoro-4-iodophenyl)-2-nitroaniline

: 1084331-65-6
5-fluoro-N-(2-fluoro-4-iodophenyl)-2-nitro-3-(2-piperidin-4-ylethoxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 - 90 °C

1.2: 0.5 h

2.1: hydrogenchloride / water; acetonitrile / 1 h / 20 °C

With hydrogenchloride; sodium hydride; In water; N,N-dimethyl-formamide; acetonitrile;