methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

Base Information

Chemical Name:methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate
CAS No.:1245623-65-7
Molecular Formula:C₁₄H₁₃ClF₃N₃O₃
Molecular Weight:363.724
Hs Code.:

Synonyms:methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

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Chemical Property of methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

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Technology Process of methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

There total 8 articles about methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1245622-74-5
methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate

: 1245623-65-7
methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

Guidance literature:: With hydrogen; platinum on carbon; In methanol;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1245623-65-7
methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: 20 °C / pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: Preparative HPLC, chiral silica gel phase based on selector poly(N-methacryloyl-L-isoleusine-3-pentylamide / ethyl acetate; 2-Methylpentane / Resolution of racemate

7.1: dmap; trifluoromethanesulfonic acid anhydride / pyridine / 18 h / 20 °C

8.1: hydrogen; platinum on carbon / methanol / 18 h / 760.05 Torr

With pyridine; methanol; dmap; sodium tetrahydroborate; platinum on carbon; water; hydrogen; potassium carbonate; trifluoromethanesulfonic acid anhydride; potassium iodide; sodium hydroxide; In tetrahydrofuran; pyridine; methanol; 2-Methylpentane; ethyl acetate; acetonitrile;

Reference yield:

: 1228650-21-2
ethyl N-({2-[(4-chlorophenyl)carbonyl]hydrazinyl}carbonyl)glycinate

: 1245623-65-7
methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / Reflux

1.2: 20 °C / pH 1

2.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

2.2: 70 °C

3.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

4.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

5.1: Preparative HPLC, chiral silica gel phase based on selector poly(N-methacryloyl-L-isoleusine-3-pentylamide / ethyl acetate; 2-Methylpentane / Resolution of racemate

6.1: dmap; trifluoromethanesulfonic acid anhydride / pyridine / 18 h / 20 °C

7.1: hydrogen; platinum on carbon / methanol / 18 h / 760.05 Torr

With pyridine; methanol; dmap; sodium tetrahydroborate; platinum on carbon; water; hydrogen; potassium carbonate; trifluoromethanesulfonic acid anhydride; potassium iodide; sodium hydroxide; In pyridine; methanol; 2-Methylpentane; ethyl acetate; acetonitrile;