(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

Base Information

Chemical Name:(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester
CAS No.:258850-21-4
Molecular Formula:C₁₆H₁₇ClN₂O₂
Molecular Weight:304.776
Hs Code.:

Synonyms:(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

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Chemical Property of (+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

Chemical Property:

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Technology Process of (+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

There total 3 articles about (+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73033-58-6
5-chloro-2-nitrobenzyl alcohol

: 258850-21-4
(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / toluene / 2 h / 5 °C

2: 43 percent / Et₃N / tetrahydrofuran / Heating

3: 89 percent / hydrazine hydrate / RaNi / methanol / Heating

With hydrazine hydrate; triethylamine; RaNi; In tetrahydrofuran; methanol; toluene; 1: Esterification / 2: Substitution / 3: Reduction;
DOI:10.1016/S0968-0896(99)00198-4

Reference yield:

: 15028-40-7,13226-98-7
DL-2-phenylglycine methyl ester hydrochloride

: 258850-21-4
(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / Et₃N / tetrahydrofuran / Heating

2: 89 percent / hydrazine hydrate / RaNi / methanol / Heating

With hydrazine hydrate; triethylamine; RaNi; In tetrahydrofuran; methanol; 1: Substitution / 2: Reduction;
DOI:10.1016/S0968-0896(99)00198-4

Reference yield:

: 209688-13-1
5-chloro-2-nitrobenzyl methanesulfonate

: 258850-21-4
(+/-)-α-[[(2-amino-5-chlorophenyl)methyl]amino]benzeneacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / Et₃N / tetrahydrofuran / Heating

2: 89 percent / hydrazine hydrate / RaNi / methanol / Heating

With hydrazine hydrate; triethylamine; RaNi; In tetrahydrofuran; methanol; 1: Substitution / 2: Reduction;
DOI:10.1016/S0968-0896(99)00198-4