methyl 2-amino-2-phenylacetate hydrochloride

Base Information

• Chemical Name: methyl 2-amino-2-phenylacetate hydrochloride
• CAS No.: 15028-40-7
• Molecular Formula: C9H11NO2.ClH
• Molecular Weight: 201.653
• Hs Code.: 2922499990
• Mol file: 15028-40-7.mol

Synonyms:(RS)-phenylglycine methyl ester hydrochloride;(+/-)-phenylglycine methyl ester hydrochloride;

Chemical Property of methyl 2-amino-2-phenylacetate hydrochloride

Chemical Property:

• Melting Point: 202 °C
• PSA: 52.32000
• LogP: 2.36170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

PhenylglycineMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Phenylglycine Methyl Ester Hydrochloride, is a substituted Glycine derivative, used as an intermediate for the synthesis of various pharmaceutical compounds. It is also a compound involved in the enzymic synthesis of D-(-)-α-Aminobenzyl penicillin by Penicillin Acylase.

Technology Process of methyl 2-amino-2-phenylacetate hydrochloride

There total 12 articles about methyl 2-amino-2-phenylacetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + phenylglycin (2835-06-5) → DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7)

Guidance literature:

With thionyl chloride; at 0 ℃; for 6h;

Reference yield: 93.0%

methyl Nα-(diphenylmethylene)-DL-phenylglycinate (171181-53-6) → DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 25 ℃; for 4h; Schlenk technique;

DOI:10.1002/chem.201604623

Reference yield: 67.0%

→ DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7)

Guidance literature:

upstream raw materials:

(S)-Methyl mandelate

N-benzylidene benzylamine

carbonic acid dimethyl ester

methanol

Downstream raw materials:

methyl 2-phenyl-2-((trifluoromethyl)sulfonamido)acetate

N-Triphenylmethyl-α-amino-phenylessigsaeure-methylester

methyl N-3-pyridylmethylene(phenyl)glycinate

methyl N-2-furylmethylene(phenyl)glycinate