(E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

Base Information

Chemical Name:(E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide
CAS No.:1508307-41-2
Molecular Formula:C₂₂H₂₃BrN₂O
Molecular Weight:411.341
Hs Code.:

Synonyms:(E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

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Chemical Property of (E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

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Technology Process of (E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

There total 2 articles about (E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769-92-6
4-tert-Butylaniline

: 1508307-18-3
(E)-3-(6-bromo-1H-indol-3-yl)-2-methylacrylic acid

: 1508307-41-2
(E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

Guidance literature:: (E)-3-(6-bromo-1H-indol-3-yl)-2-methylacrylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

4-tert-Butylaniline; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.01.062

Reference yield:

: 17826-04-9
6-bromo-1H-indole-3-carbaldehyde

: 1508307-41-2
(E)-3-(6-bromo-1H-indol-3-yl)-N-(4-tert-butylphenyl)-2-methylacrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 5 °C / Inert atmosphere; Reflux

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide; dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Wittig Olefination;
DOI:10.1016/j.ejmech.2014.01.062