(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

Base Information

• Chemical Name: (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid
• CAS No.: 138694-13-0
• Molecular Formula: C₁₃H₁₇NO₇
• Molecular Weight: 299.28
• Mol file: 138694-13-0.mol

Synonyms:(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

Chemical Property of (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

There total 1 articles about (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone (134333-52-1) → (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid (138694-13-0)

Guidance literature:

With lithium hydrogen peroxide; In tetrahydrofuran; water; at 0 ℃;

DOI:10.1021/jo00030a006

Reference yield:

(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid (138694-13-0) → (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride (138694-32-3)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃;

DOI:10.1021/jo00030a006

Reference yield:

(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid (138694-13-0) → (4R,3R)-4-(2,5-Dimethoxy-3-nitrophenyl)-4-methoxy-3-methylbutaoic acid (138694-15-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

2: CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

3: 87 percent / AgNO₃, H₂O / tetrahydrofuran / 23 h / 25 °C

With oxalyl dichloride; water; silver nitrate; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jo00054a035

upstream raw materials:

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Downstream raw materials:

(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

(4R,3R)-4-(2,5-Dimethoxy-3-nitrophenyl)-4-methoxy-3-methylbutaoic acid

(4R,3R)-1-Diazo-4-(2,5-dimethoxy-3-nitrophenyl)-4-methoxy-3-methyl-2-butanone

3-<(3S,4R)-4-(2,5-Dimethoxy-3-nitrophenyl)-4-methoxy-3-methylbutyryl>-2-thiazolidinethione