(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

Base Information

Chemical Name:(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride
CAS No.:138694-32-3
Molecular Formula:C₁₃H₁₆ClNO₆
Molecular Weight:317.726
Hs Code.:

Synonyms:(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

Chemical Property:

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Technology Process of (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

There total 2 articles about (2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138694-13-0
(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionic acid

: 138694-32-3
(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃;
DOI:10.1021/jo00030a006

Reference yield:

: 134333-52-1
(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

: 138694-32-3
(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 30percent aq. H₂O₂, sodium lithium hydroxide / tetrahydrofuran; H₂O / 0.5 h / 0 °C

2: (COCl)2, DMF / CH₂Cl₂ / 16 h / Ambient temperature

With oxalyl dichloride; sodium lithium hydroxide; dihydrogen peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00054a035

Reference yield:

: 138694-32-3
(2R,3R)-(2,5-Dimethoxy-3-nitrophenyl)-3-methoxy-2-methylpropionyl chloride

: 138721-95-6
(2R,3R,4E,6S,7R,10S,11R)-3-(tert-Butyldimethylsilyloxy)-11-(2,5-dimethoxy-3-nitrophenyl)-8-hydroxy-N,7,11-trimethoxy-N,2,4,6,10-pentamethyl-9-<(2-thioxo-3-thiazolidinyl)carbonyl>-4-undecenamide

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂; diethyl ether / 0.5 h / 0 °C

2: 87 percent / AgNO₃, H₂O / tetrahydrofuran / 23 h / 25 °C

3: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide*HCl, DMAP / CH₂Cl₂ / 24 h

4: 1) TiCl₄, Et₃N / 1) CH₂Cl₂, 1 h, 0 deg C, 2) CH₂Cl₂, 0 deg C, 3.3 h

With dmap; water; titanium tetrachloride; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jo00054a035