[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid
CAS No.:1233248-24-2
Molecular Formula:C₂₅H₁₈Cl₂N₂O₃
Molecular Weight:465.336
Hs Code.:

Synonyms:[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

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Chemical Property of [1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

Chemical Property:

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Technology Process of [1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

There total 8 articles about [1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-81-4
methyl [1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetate

: 1233248-24-2
[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; for 0.333333h; Cooling with ice;

Reference yield:

: 3544-25-0
p-aminophenylacetonitrile

: 1233248-24-2
[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

4.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

4.2: 2 h / Cooling with ice

5.1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1.25 h / Cooling with ice

6.2: 14 h / 60 °C

7.1: pyridine / 14 h / 20 °C / Cooling with ice

8.1: sodium hydroxide / water; tetrahydrofuran; methanol / 0.33 h / Cooling with ice

With pyridine; sodium tetrahydroborate; oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; chloroform; water;

Reference yield:

: 1233249-80-3
methyl [1-(4-amino benzyl)isoquinolin-4-yl]acetate

: 1233248-24-2
[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 14 h / 20 °C / Cooling with ice

2: sodium hydroxide / water; tetrahydrofuran; methanol / 0.33 h / Cooling with ice

With pyridine; sodium hydroxide; In tetrahydrofuran; methanol; water;