1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

Base Information

• Chemical Name: 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid
• CAS No.: 1233249-37-0
• Molecular Formula: C₂₂H₂₀N₂O₅
• Molecular Weight: 392.411
• Mol file: 1233249-37-0.mol

Synonyms:1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

Chemical Property of 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

There total 4 articles about 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate (1233249-36-9) → 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid (1233249-37-0)

Guidance literature:

With methanol; water; sodium hydroxide; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid (1233249-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

With water; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

p-aminophenylacetonitrile (3544-25-0) → 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid (1233249-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 2 h / 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

2.2: 2.5 h / 20 °C / Cooling with ice

2.3: 17 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

With water; sodium hexamethyldisilazane; sodium hydroxide; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

di-tert-butyl dicarbonate

p-aminophenylacetonitrile

methyl 1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylate

Downstream raw materials:

2-[1-[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]isoquinolin-4-yl]acetic acid

[1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetic acid

methyl [1-(4-amino benzyl)isoquinolin-4-yl]acetate

methyl [1-(4-{[(3,4-dichlorophenyl)carbonyl]amino}benzyl)isoquinolin-4-yl]acetate