4',4''-(Hexamethylenedioxy)-diacetanilide

Base Information

• Chemical Name: 4',4''-(Hexamethylenedioxy)-diacetanilide
• CAS No.: 104209-29-2
• Molecular Formula: C₂₂H₂₈N₂O₄
• Molecular Weight: 384.475
• European Community (EC) Number: 653-210-5
• Mol file: 104209-29-2.mol

Synonyms:4',4''-(HEXAMETHYLENEDIOXY)-DIACETANILIDE;AKOS024430376;N,N'-((Hexane-1,6-diylbis(oxy))bis(4,1-phenylene))diacetamide

Chemical Property of 4',4''-(Hexamethylenedioxy)-diacetanilide

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 384.20490738
• Heavy Atom Count: 28
• Complexity: 414

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)OCCCCCCOC2=CC=C(C=C2)NC(=O)C

Technology Process of 4',4''-(Hexamethylenedioxy)-diacetanilide

There total 1 articles about 4',4''-(Hexamethylenedioxy)-diacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1 ,6-dibromohexane (629-03-8) + 4-acetaminophenol (103-90-2,8055-08-1) → N,N′-((hexane-1,6-diylbis(oxy))bis(4,1-phenylene))diacetamide (104209-29-2)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1007/s10847-021-01103-4

Reference yield: 92.0%

N,N′-((hexane-1,6-diylbis(oxy))bis(4,1-phenylene))diacetamide (104209-29-2) → 1,6-bis-(4-aminophenoxy)-hexane (47244-09-7)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1021/ma0502304

Reference yield:

N,N′-((hexane-1,6-diylbis(oxy))bis(4,1-phenylene))diacetamide (104209-29-2) → C70H76N6O8

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / NaOH / ethanol

2: toluene-4-sulfonic acid / ethanol

With sodium hydroxide; toluene-4-sulfonic acid; In ethanol;

DOI:10.1021/ma0502304

upstream raw materials:

1 ,6-dibromohexane

4-acetaminophenol

Downstream raw materials:

4,4'-<1,6-hexanediylbis(oxy)>bis dihydrochloride

1,6-bis-(4-aminophenoxy)-hexane