3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil

Base Information

• Chemical Name: 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil
• CAS No.: 1425368-11-1
• Molecular Formula: C₃₀H₃₇FN₄O₁₀Si
• Molecular Weight: 660.728

Synonyms:3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil

Chemical Property of 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil

There total 2 articles about 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzylalcohol (1425368-09-7) + N1-Benzoyl-5-fluorouracil (54390-98-6) → 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil (1425368-11-1)

Guidance literature:

With diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -20 - 20 ℃; for 15.5h;

DOI:10.1016/j.jphotochem.2012.08.012

Reference yield:

tert-butyl((5-iodopentyl)oxy)dimethylsilane (85514-45-0) → 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil (1425368-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

2: diisopropyl (E)-azodicarboxylate; triphenylphosphine / tetrahydrofuran / 15.5 h / -20 - 20 °C

With potassium carbonate; diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.jphotochem.2012.08.012

Reference yield:

3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil (1425368-11-1) → C17H19FN4O9

Guidance literature:

With hydrogenchloride; In methanol; at 60 ℃; for 15h;

DOI:10.1016/j.jphotochem.2012.08.012

upstream raw materials:

3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzylalcohol

N¹-Benzoyl-5-fluorouracil

tert-butyl((5-iodopentyl)oxy)dimethylsilane

Downstream raw materials:

3-N-(3-(5-methacryloxypentyloxy)-4-methoxy-2,6-dinitrobenzyl)-5-fluorouracil

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1425368-11-1 3-N-(3-(5-(tert-butyldimethylsilyloxy)pentyloxy)-4-methoxy-2,6-dinitrobenzyl)-1-N-benzoyl-5-fluoro-uracil

Send

Send

Metric Ton KG G Pound L ML

Send

Send