Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Base Information

Chemical Name:Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate
CAS No.:23781-00-2
Molecular Formula:C15H21 N O3
Molecular Weight:263.337
Hs Code.:
NSC Number:116043
DSSTox Substance ID:DTXSID00297458
Wikidata:Q82038562

Synonyms:ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate;23781-00-2;NSC116043;SCHEMBL6530831;DTXSID00297458;DQQMUKDYUGBROV-UHFFFAOYSA-N;AKOS005215895;NSC-116043;FT-0747367;1-Benzyl-4-ethoxycarbonyl-4-hydroxypiperidine

Suppliers and Price of Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Chemical Property:

Vapor Pressure:4.1E-06mmHg at 25°C
Boiling Point:369.5°C at 760 mmHg
Flash Point:177.3°C
Density:1.168g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:292

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(CCN(CC1)CC2=CC=CC=C2)O

Technology Process of Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

There total 5 articles about Ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 6094-60-6
1-benzyl-4-hydroxypiperidine-4-carbonitrile

: 23781-00-2
ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Guidance literature:: 1-benzyl-4-hydroxypiperidine-4-carbonitrile; With hydrogenchloride; In water; at 100 ℃; for 4h;

ethanol; With toluene-4-sulfonic acid; at 105 ℃; for 5h;
DOI:10.1016/j.bmc.2016.02.014

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 23781-00-2
ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. H₂SO₄ / 20 °C

2: conc. HCl / Heating

3: HCl / Heating

With hydrogenchloride; sulfuric acid;
DOI:10.1016/j.bmcl.2007.06.054

Reference yield:

: 6094-60-6
1-benzyl-4-hydroxypiperidine-4-carbonitrile

: 23781-00-2
ethyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: conc. HCl / Heating

2: HCl / Heating

With hydrogenchloride;
DOI:10.1016/j.bmcl.2007.06.054