2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

Base Information

• Chemical Name: 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan
• CAS No.: 70610-22-9
• Molecular Formula: C₂₀H₂₂O₆
• Molecular Weight: 358.391
• Mol file: 70610-22-9.mol

Synonyms:2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

Chemical Property of 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

There total 31 articles about 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde (135040-83-4) → 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan (70610-22-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1021/jo00052a046

Reference yield: 61.0%

5-(2-Ethoxycarbonyl-ethyl)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester (242474-37-9) → 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan (70610-22-9)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane;

DOI:10.1016/S0040-4039(98)01371-9

Reference yield:

pittogoside B → β-D-glucose (492-61-5) + 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan (70610-22-9)

Guidance literature:

With water; cellulase; In chloroform; at 40 ℃; for 96h; Enzymatic reaction;

DOI:10.1016/j.phytol.2012.01.003

upstream raw materials:

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde

5-(2-Ethoxycarbonyl-ethyl)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

(E)-2-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-5-(3-hydroxyprop-1-en-1-yl)-7-methoxybenzofuran

2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-5-(2-methoxycarbonyl-ethyl)-benzofuran-3-carboxylic acid methyl ester

Downstream raw materials:

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde