(-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt

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Chemical Name:(-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt
CAS No.:1243634-57-2
Molecular Formula:CH₄O₃S*C₁₁H₁₉NO₃
Molecular Weight:309.384
Hs Code.:

Synonyms:(-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt

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Chemical Property of (-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt

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Technology Process of (-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt

There total 1 articles about (-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29021-98-5
3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol

: 1243634-57-2
(-)-methyl (1R,2R,3S,5S)-3-(hydroxy)-1,8-dimethyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 11 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere

1.2: 1.25 h / -78 - 20 °C / Inert atmosphere

2.1: dichloromethane / 17 h / 20 °C

3.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / -78 °C / Inert atmosphere

4.1: manganese(IV) oxide / dichloromethane / 24 h

5.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / chloroform / 41 h / 4 °C

6.1: chloroform / 2 h / 20 °C

7.1: triethylsilane; triethylamine; palladium dichloride / dichloromethane / 8 h / Inert atmosphere; Reflux

8.1: hydrogenchloride; water / tetrahydrofuran / 2 h / 20 °C

9.1: aluminum tri-tert-butoxide / toluene / 68 h / 20 - 150 °C / pressure tube

10.1: benzene / 24 h / 85 °C

11.1: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 20 °C / 2585.81 - 3620.13 Torr

With hydrogenchloride; triethylsilane; manganese(IV) oxide; oxalyl dichloride; (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; palladium 10% on activated carbon; water; hydrogen; diisobutylaluminium hydride; aluminum tri-tert-butoxide; dimethyl sulfoxide; triethylamine; palladium dichloride; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; toluene; benzene; 2.1: Wittig reaction / 5.1: Michael condensation / 6.1: Wittig reaction / 10.1: sealed pressure tube;
DOI:10.1002/adsc.201100917