4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:1188543-31-8
Molecular Formula:C₂₄H₃₁N₅O₅
Molecular Weight:469.541
Hs Code.:

Synonyms:4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

There total 12 articles about 4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1188543-30-7
4-{4-[2,6-dioxo-1,3-dipropyl-7-(2-trimethylsilanyl-ethoxymethyl)-2,3,6,7-tetrahydro-1H-purin-8-yl]-phenoxymethyl}-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1188543-31-8
4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; In methanol; at 0 - 20 ℃;

Reference yield:

: 1486-51-7
p-(benzyloxy)benzoic acid

: 1188543-31-8
4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 h / 20 °C

2: sodium hydroxide / methanol / 3 h / 80 - 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6: hydrogenchloride / methanol / 0 - 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1188541-40-3
N-(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-benzyloxy-benzamide

: 1188543-31-8
4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxymethyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / methanol / 3 h / 80 - 90 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

5: hydrogenchloride / methanol / 0 - 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; sodium hydroxide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;