α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

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Chemical Name:α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester
CAS No.:301220-17-7
Molecular Formula:C₃₉H₄₈N₄O₃
Molecular Weight:620.835
Hs Code.:

Synonyms:α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

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Chemical Property of α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

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Technology Process of α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

There total 6 articles about α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 300854-17-5
α-(R)-(3-(R)-Formyl-4-(S)-phenyl-pyrrolidin-1-yl)cyclohexaneacetic acid, para-methoxybenzyl ester

: 1-piperidin-4-yl-1-H-benzoimidazole

: 301220-17-7
α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; silica gel; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 301220-17-7
α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH(OAc)3 / CH₂Cl₂

2: aq. HCl / Heating

3: HCO₂NH₄ / Pd/C / methanol

4: NaBH(OAc)3 / CH₂Cl₂

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.02.030

Reference yield:

: 57718-47-5
N-(1-benzyl-piperidin-4-yl)-benzene-1,2-diamine

: 301220-17-7
α-(R)-(3-(S)-((4-Benzoimidazol-1-yl-piperidin-1-yl)methyl)4-(S)-phenyl-pyrrolidin-1-yl)-cyclohexaneacetic acid, 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / Heating

2: HCO₂NH₄ / Pd/C / methanol

3: NaBH(OAc)3 / CH₂Cl₂

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.02.030