N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

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Chemical Name:N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide
CAS No.:1386447-64-8
Molecular Formula:C₂₄H₁₈Cl₂N₄O₄
Molecular Weight:497.337
Hs Code.:

Synonyms:N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

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Chemical Property of N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

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Technology Process of N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

There total 7 articles about N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.2%

: 1386448-09-4
4-chloro-3-(7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamido)benzoic acid

: 4152-90-3
m-chlorobenzylamine

: 1386447-64-8
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: 4-chloro-3-(7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamido)benzoic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

m-chlorobenzylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 45644-21-1
6-chloropyridin-2-amine

: 1386447-64-8
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: N,N,N',N'-Tetraethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C

2.3: -10 °C / pH 2 - 3

3.1: methanol / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

5.1: piperidine / acetic acid / methanol / 18 h / 60 °C

6.1: sodium hydroxide; water / methanol / 18 h / 65 °C

6.2: pH ~ 2 - 3

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.2: 18 h / 20 °C

8.1: sodium hydroxide; water / methanol / 18 h / Reflux

8.2: pH 2

9.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

9.2: 18 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; N,N,N',N'-Tetraethylethylenediamine; water; sodium hexamethyldisilazane; triethylamine; HATU; sodium hydroxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 159603-71-1
t-butyl N-(6-chloro-2-pyridinyl)carbamate

: 1386447-64-8
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N,N',N'-Tetraethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -10 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C

1.3: -10 °C / pH 2 - 3

2.1: methanol / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

4.1: piperidine / acetic acid / methanol / 18 h / 60 °C

5.1: sodium hydroxide; water / methanol / 18 h / 65 °C

5.2: pH ~ 2 - 3

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 18 h / 20 °C

7.1: sodium hydroxide; water / methanol / 18 h / Reflux

7.2: pH 2

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

8.2: 18 h / 20 °C

With piperidine; hydrogenchloride; n-butyllithium; N,N,N',N'-Tetraethylethylenediamine; water; triethylamine; HATU; sodium hydroxide; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; N,N-dimethyl-formamide;