methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

Base Information

Chemical Name:methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate
CAS No.:1233249-51-8
Molecular Formula:C₂₆H₂₀Cl₂N₂O₃
Molecular Weight:479.362
Hs Code.:

Synonyms:methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Chemical Property of methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

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Technology Process of methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

There total 9 articles about methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1233249-39-2
methyl 1-[4-(aminophenyl)carbonyl]isoquinolin-4-ylacetate

: 18880-04-1
3,4-dichlorobenzyl bromide

: 1233249-51-8
methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/j.bmcl.2012.03.009

Reference yield:

: 1233249-37-0
1-{4-(tert-butoxycarbonylamino)phenylcarbonyl}isoquinolin-4-ylcarboxylic acid

: 1233249-51-8
methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

1.2: 2 h / Cooling with ice

2.1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Reflux

With oxalyl dichloride; potassium carbonate; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1233249-35-8
4-tert-butoxycarbonylaminophenylacetonitrile

: 1233249-51-8
methyl [1-({4-[(3,4-dichlorobenzyl)amino]phenyl}carbonyl)isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 2.5 h / 20 °C / Cooling with ice

1.3: 17 h / 20 °C

2.1: sodium hydroxide; water / methanol / 18 h / 20 - 35 °C

3.1: oxalyl dichloride / chloroform / 3.5 h / 20 °C / Cooling with ice

3.2: 2 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 1.5 h / 20 °C / Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Reflux

With oxalyl dichloride; water; sodium hexamethyldisilazane; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;