(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Base Information

Chemical Name:(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol
CAS No.:114846-99-0
Molecular Formula:C₂₅H₃₂O₅
Molecular Weight:412.526
Hs Code.:

Synonyms:(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Suppliers and Price of (1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

There total 5 articles about (1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 114826-80-1
1-((1S,2R,3S,5R)-3-Benzyloxy-2-benzyloxymethyl-5-hydroxy-cyclopentyl)-ethane-1,2-diol

: 77-76-9
2,2-dimethoxy-propane

: 114846-99-0
(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Ambient temperature;
DOI:10.1016/S0040-4039(01)91379-6

Reference yield:

: 34638-25-0,38110-77-9,43119-28-4,54483-22-6,26054-46-6
(1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one

: 114846-99-0
(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Guidance literature:: Multi-step reaction with 5 steps

1: 1) H₂SO₄, AcOH; / 1) 60 deg C, 1 day; 2) Amberlite IR-120(H⁺), 70 deg C, 15 h

2: 60 percent / NaH / dimethylformamide

3: LDA, MoOPH / tetrahydrofuran / 9 h / -78 - 20 °C

4: 91 percent / LiAlH₄ / diethyl ether / Heating

5: 80 percent / p-TsOH / benzene / Ambient temperature

With lithium aluminium tetrahydride; MoO₅*pyridine*HMPA; sulfuric acid; sodium hydride; toluene-4-sulfonic acid; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(01)91379-6

Reference yield:

: 114826-79-8
(3aS,4R,5S,6aR)-5-Benzyloxy-4-benzyloxymethyl-hexahydro-cyclopenta[b]furan-2-one

: 114846-99-0
(1R,2S,3R,4S)-4-Benzyloxy-3-benzyloxymethyl-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1: LDA, MoOPH / tetrahydrofuran / 9 h / -78 - 20 °C

2: 91 percent / LiAlH₄ / diethyl ether / Heating

3: 80 percent / p-TsOH / benzene / Ambient temperature

With lithium aluminium tetrahydride; MoO₅*pyridine*HMPA; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/S0040-4039(01)91379-6