4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Base Information

Chemical Name:4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate
CAS No.:1360917-91-4
Molecular Formula:C₂HF₃O₂*C₂₅H₂₅F₃N₂O₅
Molecular Weight:604.503
Hs Code.:

Synonyms:4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

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Chemical Property of 4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

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Technology Process of 4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

There total 6 articles about 4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₇F₃N₂O₅

: 76-05-1
trifluoroacetic acid

: 1360917-91-4
4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Guidance literature:: C₂₆H₂₇F₃N₂O₅; With water; lithium hydroxide; In tetrahydrofuran; at 70 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1360917-91-4
4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: acetic acid / N,N-dimethyl-formamide

4: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C

5: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With hydrogenchloride; potassium phosphate; water; caesium carbonate; acetic acid; lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1360917-93-6
methyl 4-{8-[3-bromo-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

: 1360917-91-4
4-{8-[3-cyclopropyl-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 100 °C

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With potassium phosphate; water; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; toluene;