4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

Base Information

Chemical Name:4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide
CAS No.:1024589-63-6
Molecular Formula:C₁₈H₁₇BrClN₅O₂
Molecular Weight:450.722
Hs Code.:

Synonyms:4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

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Chemical Property of 4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

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Technology Process of 4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

There total 1 articles about 4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1024589-62-5
5-chloro-4-[1-(tetrahydro-2H-pyran-4-yl)hydrazino]-2-pyrimidinecarbonitrile

: 876-07-3
4-(bromomethyl)benzoyl bromide

: 1024589-63-6
4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1024589-63-6
4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

: 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine

: 76-05-1
trifluoroacetic acid

: 1024588-24-6
N'-(5-chloro-2-cyano-4-pyrimidinyl)-4-{[4-(4-methyl-1-piperazinyl)-1-piperidinyl]methyl}-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide trifluoroacetate

Guidance literature:: 4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide; 1-methyl-4-(piperidin-4-yl)piperazine; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 496808-04-9
4-[(1-methyl-4-piperidinyl)methyl]piperazine

: 1024589-63-6
4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide

: 76-05-1
trifluoroacetic acid

: 1024588-26-8
N'-(5-chloro-2-cyano-4-pyrimidinyl)-4-({4-[(1-methyl-4-piperidinyl)methyl]-1-piperazinyl}methyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide trifluoroacetate

Guidance literature:: 4-[(1-methyl-4-piperidinyl)methyl]piperazine; 4-(bromomethyl)-N'-(5-chloro-2-cyano-4-pyrimidinyl)-N'-(tetrahydro-2H-pyran-4-yl)benzohydrazide; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;