methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Base Information

Chemical Name:methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate
CAS No.:340733-41-7
Molecular Formula:C₂₉H₄₄N₄O₈
Molecular Weight:576.69
Hs Code.:

Synonyms:methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

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Chemical Property of methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

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Technology Process of methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

There total 1 articles about methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 340733-39-3
methyl 2-[(2S)-1-[(2S)-3-(4-aminophenyl)-2-[(tert-butoxycarbonyl)amino]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 340733-41-7
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1248/cpb.49.258

Reference yield:

: 340733-41-7
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: {4-[2-amino-3-(4-dimethylamino-phenyl)-propionyl]-3-methoxycarbonylmethyl-2-oxo-piperazin-1-yl}-acetic acid

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 1h;
DOI:10.1248/cpb.49.258

Reference yield:

: 340733-41-7
methyl 2-[(2S)-1-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(dimethylamino)phenyl]propanoyl]-4-[2-(tert-butoxy)-2-oxoethyl]-3-oxopiperazinyl]acetate

: {4-[2-(4-carbamimidoyl-benzoylamino)-3-(4-dimethylamino-phenyl)-propionyl]-3-methoxycarbonylmethyl-2-oxo-piperazin-1-yl}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃COOH / toluene / 1 h / 20 °C

2: NaHCO₃ / H₂O; dioxane / 0.5 h / 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; water; toluene;
DOI:10.1248/cpb.49.258