5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

Base Information

Chemical Name:5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid
CAS No.:1264836-42-1
Molecular Formula:C₂₅H₃₅N₃O₁₀
Molecular Weight:537.567
Hs Code.:

Synonyms:5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

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Chemical Property of 5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

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Technology Process of 5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

There total 6 articles about 5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.8%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1264836-41-0
C₁₅H₂₅N₃

: 1264836-42-1
5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

Guidance literature:: bromoacetic acid tert-butyl ester; C₁₅H₂₅N₃; With potassium carbonate; In acetonitrile; at 70 ℃; for 48h; pH=10;

With hydrogenchloride; In acetonitrile; at 20 ℃; for 24h;

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 1264836-42-1
5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 15 h / 20 °C

2: borane-THF / tetrahydrofuran

3: potassium carbonate / acetonitrile / 90 °C

With borane-THF; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ic101799c

Reference yield:

: 38932-71-7
1,1-di(aminomethyl)-cyclobutane

: 1264836-42-1
5-benzyl-6-carboxymethyl-3-{{[1-(N,N-dicarboxymethyl)-2'-aminomethyl]-cyclobut-1'-yl}methyl}-3,6-diazaoctanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 15 h / 20 °C

2: borane-THF / tetrahydrofuran

3: potassium carbonate / acetonitrile / 90 °C

With borane-THF; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ic101799c