{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

Base Information

Chemical Name:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester
CAS No.:1026938-60-2
Molecular Formula:C₄₀H₄₇N₉O₁₂
Molecular Weight:845.866
Hs Code.:

{[(4-benzyloxycarbonylamino-2-oxo-2<i>H</i>-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-<i>tert</i>-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

Synonyms:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

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Chemical Property of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

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Technology Process of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

There total 9 articles about {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 1026938-60-2
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / pyridine / CH₂Cl₂ / 1.5 h

2: 58 percent / PPh₃; CBr₄ / tetrahydrofuran / 2 h / 20 °C

3: 92 percent / DIPEA / dimethylformamide / 20 °C

4: 72 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

5: 91 percent / Bu₃SnH; Pd(PPh₃)4 / CH₂Cl₂; H₂O / 0.25 h

6: 69 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo001650o

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1026938-60-2
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: 96 percent / K₂CO₃ / CHCl₃; acetonitrile

3: EDC / dimethylformamide

4: LiOH; H₂O / tetrahydrofuran

5: 69 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

With lithium hydroxide; water; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo001650o

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1026938-60-2
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / K₂CO₃ / CHCl₃; acetonitrile

2: EDC / dimethylformamide

3: LiOH; H₂O / tetrahydrofuran

4: 69 percent / HATU; DIPEA / dimethylformamide / 0 - 20 °C

With lithium hydroxide; water; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo001650o