1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate
CAS No.:1179343-97-5
Molecular Formula:C₃₀H₃₄ClFN₄O₃
Molecular Weight:553.076
Hs Code.:

Synonyms:1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 865314-22-3
1,1-dimethylethyl (2S)-4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

: 1179343-97-5
1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 19h;

Reference yield: 69.0%

: 931405-72-0
5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

: 1179343-97-5
1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

: 1179344-22-9
1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: With benzyl tri-n-butylammonium bromide; caesium carbonate; palladium diacetate; In water; toluene; at 150 ℃; for 2h; Product distribution / selectivity; Microwave irradiation; Inert atmosphere;

Reference yield:

: 931405-72-0
5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

: 1179343-97-5
1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

: 1179344-21-8
6-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-N-[(6-fluoro-3'-{[(3S)-3-methyl-1-piperazinyl]methyl}-3-biphenylyl)methyl]-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzyl tri-n-butylammonium bromide; caesium carbonate / palladium diacetate / water; toluene / 2 h / 150 °C / Microwave irradiation; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.2: amine cartridge

With benzyl tri-n-butylammonium bromide; caesium carbonate; trifluoroacetic acid; palladium diacetate; In dichloromethane; water; toluene;