1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

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Chemical Name:1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate
CAS No.:1179344-22-9
Molecular Formula:C₄₆H₅₈FN₉O₄
Molecular Weight:820.023
Hs Code.:

1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

Synonyms:1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

There total 10 articles about 1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 931405-72-0
5-(aminomethyl)-1,6-diethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

: 1179343-97-5
1,1-dimethylethyl (2S)-4-{[5'-({[(6-chloro-3-pyridinyl)carbonyl]amino}methyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate

: 1179344-22-9
1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: With benzyl tri-n-butylammonium bromide; caesium carbonate; palladium diacetate; In water; toluene; at 150 ℃; for 2h; Product distribution / selectivity; Microwave irradiation; Inert atmosphere;

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1179344-22-9
1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 19 h / 20 °C

2: benzyl tri-n-butylammonium bromide; caesium carbonate / palladium diacetate / water; toluene / 2 h / 150 °C / Microwave irradiation; Inert atmosphere

With benzyl tri-n-butylammonium bromide; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium diacetate; In dichloromethane; water; toluene;

Reference yield:

: 21633-77-2
diethyl 2-propionylmalonate

: 1179344-22-9
1,1-dimethylethyl (2S)-4-({5'-[({[2-({[1,6-diethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl}amino)-5-pyridinyl]carbonyl}amino)methyl]-2'-fluoro-3-biphenylyl}methyl)-2-methyl-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tributyl-amine; trichlorophosphate / 22 h / 20 - 115 °C

2.1: triethylamine / toluene / 6 h / Reflux

2.2: 17.5 h / 110 °C

3.1: 1-Methylpyrrolidine; N-ethyl-N,N-diisopropylamine / 16 h / Reflux

4.1: methanol; lithium borohydride / tetrahydrofuran / 2.5 h / Reflux

5.1: thionyl chloride / 0.5 h / 20 °C

6.1: sodium azide / dimethyl sulfoxide / 16 h

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

8.1: benzyl tri-n-butylammonium bromide; caesium carbonate / palladium diacetate / water; toluene / 2 h / 150 °C / Microwave irradiation; Inert atmosphere

With 1-Methylpyrrolidine; methanol; lithium borohydride; thionyl chloride; sodium azide; tributyl-amine; hydrogen; benzyl tri-n-butylammonium bromide; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene;