Technology Process of 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-5-hydroxyl-2-methyl-2,3-dihydro-3-pyridazinone
There total 6 articles about 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-5-hydroxyl-2-methyl-2,3-dihydro-3-pyridazinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone;
With
water; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one;
at 70 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride;
In
1-methyl-pyrrolidin-2-one; water;
pH=1;
Cooling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere
1.2: 2 h / 0 - 5 °C / Inert atmosphere
2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere
4.1: triethylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice
5.1: methanol; lithium hydroxide monohydrate / 4 h / -5 °C / Inert atmosphere
5.2: Inert atmosphere; Cooling with ice
6.1: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one / 3 h / 70 °C / Inert atmosphere
6.2: pH 1 / Cooling
With
methanol; thionyl chloride; lithium hydroxide monohydrate; water; magnesium; ethylene dibromide; triethylamine; sodium hydroxide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice
4.1: methanol; lithium hydroxide monohydrate / 4 h / -5 °C / Inert atmosphere
4.2: Inert atmosphere; Cooling with ice
5.1: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one / 3 h / 70 °C / Inert atmosphere
5.2: pH 1 / Cooling
With
methanol; thionyl chloride; lithium hydroxide monohydrate; water; triethylamine; sodium hydroxide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;
