4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

Base Information

Chemical Name:4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone
CAS No.:1363808-15-4
Molecular Formula:C₂₃H₂₅FN₂O₃S
Molecular Weight:428.528
Hs Code.:

Synonyms:4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

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Chemical Property of 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

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Technology Process of 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

There total 6 articles about 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363808-12-1
1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-[1-(4-fluorophenyl)-2-methylsulfonylethylidene]-1-methylhydrazine

: 1363808-19-8
5-[(2,6-diethyl-4-methylphenyl)carbonyl]-3-(4-fluorophenyl)-1-methyl-4-methylsulfonyl-1H-pyrazole

: 1363808-15-4
4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

Guidance literature:: 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-[1-(4-fluorophenyl)-2-methylsulfonylethylidene]-1-methylhydrazine; With methanol; lithium hydroxide monohydrate; at -5 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere; Cooling with ice;

Reference yield:

: 314084-61-2
1-bromo-2,6-diethyl-4-methylbenzene

: 1363808-15-4
4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium; ethylene dibromide / toluene; tetrahydrofuran / 52 h / 40 - 50 °C / Inert atmosphere

1.2: 2 h / 0 - 5 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

3.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

5.1: methanol; lithium hydroxide monohydrate / 4 h / -5 °C / Inert atmosphere

5.2: Inert atmosphere; Cooling with ice

With methanol; thionyl chloride; lithium hydroxide monohydrate; water; magnesium; ethylene dibromide; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 1363806-98-7
ethyl 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetate

: 1363808-15-4
4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 10 - 20 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 2 h / 50 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / Inert atmosphere; Cooling with ice

4.1: methanol; lithium hydroxide monohydrate / 4 h / -5 °C / Inert atmosphere

4.2: Inert atmosphere; Cooling with ice

With methanol; thionyl chloride; lithium hydroxide monohydrate; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;