1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate
CAS No.:1199793-53-7
Molecular Formula:C₂₈H₃₉NO₅Si
Molecular Weight:497.707
Hs Code.:

Synonyms:1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

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Chemical Property of 1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

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Technology Process of 1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

There total 2 articles about 1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1199793-52-6
(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

: 58479-61-1
tert-butylchlorodiphenylsilane

: 18107-18-1
diazomethyl-trimethyl-silane

: 1199793-53-7
1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid; diazomethyl-trimethyl-silane; In methanol; hexane; benzene; for 1h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In methanol; hexane; benzene; at 60 ℃; for 24h;

Reference yield:

: 876317-19-0
⁽²⁸⁾-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid

: 1199793-53-7
1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 11 h / -20 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: methanol; hexane; benzene / 1 h

2.2: 24 h / 60 °C

With methylmagnesium bromide; In tetrahydrofuran; methanol; diethyl ether; hexane; benzene;