(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid
CAS No.:1199793-52-6
Molecular Formula:C₁₁H₁₉NO₅
Molecular Weight:245.276
Hs Code.:

Synonyms:(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

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Technology Process of (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

There total 1 articles about (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 876317-19-0
⁽²⁸⁾-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid

: 1199793-52-6
(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

Guidance literature:: ⁽²⁸⁾-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid; With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -20 - 20 ℃; for 11h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; Cooling with ice;

Reference yield: 58.0%

: 1199793-52-6
(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

: 100-39-0
benzyl bromide

: C₁₈H₂₅NO₅

Guidance literature:: (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid; With sodium hydride; In tetrahydrofuran; at 0 - 65 ℃; for 0.5h;

benzyl bromide; In tetrahydrofuran; at 65 ℃; for 16h;

Reference yield: 39.0%

: 1199793-52-6
(2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid

: 58479-61-1
tert-butylchlorodiphenylsilane

: 18107-18-1
diazomethyl-trimethyl-silane

: 1199793-53-7
1-tert-butyl 2-methyl (2S,4S)-4-{[tert-butyl(diphenyl)silyl]oxy}-4-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: (2S,4S)-1-(tert-butoxycarbonyl)-4-hydroxy-4-methylpyrrolidine-2-carboxylic acid; diazomethyl-trimethyl-silane; In methanol; hexane; benzene; for 1h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In methanol; hexane; benzene; at 60 ℃; for 24h;