6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

Base Information

Chemical Name:6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one
CAS No.:1621132-84-0
Molecular Formula:C₃₄H₂₈O₆
Molecular Weight:532.593
Hs Code.:

Synonyms:6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

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Chemical Property of 6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

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Technology Process of 6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

There total 7 articles about 6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1621132-83-9
ethyl 2-[6-(3-(ethoxymethoxy)naphthalen-2-yl)methoxy-3-oxo-3H-xanthen-9-yl]benzoate

: 1621132-84-0
6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

Guidance literature:: ethyl 2-[6-(3-(ethoxymethoxy)naphthalen-2-yl)methoxy-3-oxo-3H-xanthen-9-yl]benzoate; With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.166667h; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; for 0.5h; Inert atmosphere;
DOI:10.1021/jo501116g

Reference yield:

: 2321-07-5,126605-73-0
fluorescein

: 1621132-84-0
6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / ethanol / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

With boron trifluoride diethyl etherate; diisobutylaluminium hydride; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2.1: |Williamson Ether Synthesis;
DOI:10.1021/jo501116g

Reference yield:

: 1621132-94-2
(3-(ethoxymethoxy)naphthalen-2-yl)methanol

: 1621132-84-0
6-((3-(ethoxymethoxy)naphthalen-2-yl)methoxy)-9-(2-(hydroxymethyl)phenyl)-8a,10a-dihydro-3H-xanthen-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine; triphenylphosphine; 1H-imidazole / dichloromethane / 0.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

With 1H-imidazole; bromine; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 2.1: |Williamson Ether Synthesis;
DOI:10.1021/jo501116g