Technology Process of (2S,3S,4S)-2-(tert-butyldimethylsilyl)oxy-5-(tert-butyldiphenylsilyl)oxy-3,4-(dimethylmethylene)dioxypentanal
There total 6 articles about (2S,3S,4S)-2-(tert-butyldimethylsilyl)oxy-5-(tert-butyldiphenylsilyl)oxy-3,4-(dimethylmethylene)dioxypentanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl (2E,4R,5S,6S)-4-(tert-butyldimethylsilyl)-oxy-7-(tert-butyldiphenylsilyl)oxy-5,6-(dimethylmethylene-dioxy)-2-heptenoate;
With
ozone;
In
dichloromethane;
at -78 ℃;
for 0.25h;
With
dimethylsulfide;
In
dichloromethane;
at 20 ℃;
for 10h;
DOI:10.1016/S0040-4020(02)01380-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97 percent / imidazole / dimethylformamide / 16 h / 0 °C
2.1: 83 percent / hydrogen / Pd(OH)2 / ethanol / 48 h
3.1: 98 percent / benzene / 32 h / Heating
4.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C
5.1: ozone / CH2Cl2 / 0.25 h / -78 °C
5.2: Me2S / CH2Cl2 / 10 h / 20 °C
With
1H-imidazole; hydrogen; ozone;
palladium dihydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
3.1: Wittig reaction;
DOI:10.1016/S0040-4020(02)01380-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 97 percent / imidazole / dimethylformamide / 16 h / 0 °C
2.1: 83 percent / hydrogen / Pd(OH)2 / ethanol / 48 h
3.1: 98 percent / benzene / 32 h / Heating
4.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C
5.1: ozone / CH2Cl2 / 0.25 h / -78 °C
5.2: Me2S / CH2Cl2 / 10 h / 20 °C
With
1H-imidazole; hydrogen; ozone;
palladium dihydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
3.1: Wittig reaction;
DOI:10.1016/S0040-4020(02)01380-7
