(3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

Base Information

• Chemical Name: (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol
• CAS No.: 117121-03-6
• Molecular Formula: C₁₃H₁₆N₂O₂S
• Molecular Weight: 264.348
• Mol file: 117121-03-6.mol

Synonyms:(3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

Chemical Property of (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

There total 2 articles about (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 1-benzyl-2-(methylthio)imidazole-4,5-dicarboxylate (1098-38-0) → (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol (117121-03-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; Yield given; a) 0 - 5 deg C, 3 h, b) room temperature, 1 h;

DOI:10.1021/jm00121a023

Reference yield:

diethyl 2-methylthio-4,5-imidazoledicarboxylate (117121-00-3) → (3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol (117121-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 3 h / Ambient temperature

2: LiAlH₄ / CH₂Cl₂; diethyl ether / a) 0 - 5 deg C, 3 h, b) room temperature, 1 h

With lithium aluminium tetrahydride; sodium hydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00121a023

Reference yield: 84.0%

(3-Benzyl-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol (117121-03-6) + Isopropyl isocyanate (1795-48-8) → Isopropyl-carbamic acid 3-benzyl-5-isopropylcarbamoyloxymethyl-2-methylsulfanyl-3H-imidazol-4-ylmethyl ester (117120-91-9)

Guidance literature:

With dibutyltin diacetate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm00121a023

upstream raw materials:

diethyl 1-benzyl-2-(methylthio)imidazole-4,5-dicarboxylate

diethyl 2-methylthio-4,5-imidazoledicarboxylate

Downstream raw materials:

Methyl-carbamic acid 3-benzyl-5-methylcarbamoyloxymethyl-2-methylsulfanyl-3H-imidazol-4-ylmethyl ester

Isopropyl-carbamic acid 3-benzyl-5-isopropylcarbamoyloxymethyl-2-methylsulfanyl-3H-imidazol-4-ylmethyl ester