(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

Base Information

Chemical Name:(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone
CAS No.:201748-34-7
Molecular Formula:C₁₂H₇ClFNO₃
Molecular Weight:267.644
Hs Code.:

Synonyms:(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

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Chemical Property of (5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

Chemical Property:

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Technology Process of (5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

There total 8 articles about (5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 162270-97-5
2-(5-chloro-4-fluoro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine

: 201748-34-7
(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

Guidance literature:: With sulfuric acid; In acetone; for 0.5h; Heating;
DOI:10.1248/cpb.45.1994

Reference yield:

: 189283-52-1
5-chloro-4-fluoro-2-hydroxybenzoic acid

: 201748-34-7
(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / acetone / 5 h / Ambient temperature

2: LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

4: sodium iodide / dimethylsulfoxide / 10 h / Ambient temperature

5: 70 percent / p-toluenesulfinate, NaH / tetrahydrofuran / 2 h / Heating

6: 96 percent / K₂CO₃, O₂ / H₂O; dimethylsulfoxide / 60 h / Ambient temperature

7: 96 percent / 1N H₂SO₄ / acetone / 0.5 h / Heating

With lithium aluminium tetrahydride; p-toluene sulfinic acid; sulfuric acid; oxygen; sodium hydride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1248/cpb.45.1994

Reference yield:

: 162271-10-5
2-Bromo-3-(methoxymethoxy)pyridine

: 201748-34-7
(5-Chloro-4-fluoro-2-hydroxy-phenyl)-(3-hydroxy-pyridin-2-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / p-toluenesulfinate, NaH / tetrahydrofuran / 2 h / Heating

2: 96 percent / K₂CO₃, O₂ / H₂O; dimethylsulfoxide / 60 h / Ambient temperature

3: 96 percent / 1N H₂SO₄ / acetone / 0.5 h / Heating

With p-toluene sulfinic acid; sulfuric acid; oxygen; sodium hydride; potassium carbonate; In tetrahydrofuran; water; dimethyl sulfoxide; acetone;
DOI:10.1248/cpb.45.1994