5-chloro-4-fluoro-2-hydroxybenzoic acid

Base Information

• Chemical Name: 5-chloro-4-fluoro-2-hydroxybenzoic acid
• CAS No.: 189283-52-1
• Molecular Formula: C7H4ClFO3
• Molecular Weight: 190.558
• Mol file: 189283-52-1.mol

Synonyms:5-chloro-4-fluorosalicylic acid;Benzoic acid,5-chloro-4-fluoro-2-hydroxy;4-fluoro-5-chlorosalicylic acid;

Chemical Property of 5-chloro-4-fluoro-2-hydroxybenzoic acid

Chemical Property:

• PSA: 57.53000
• LogP: 1.88290

Purity/Quality:

99.90% ^*data from raw suppliers

5-Chloro-4-fluoro-2-hydroxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-4-fluoro-2-hydroxybenzoic acid

There total 3 articles about 5-chloro-4-fluoro-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluorosalicylic acid (345-29-9) → 5-chloro-4-fluoro-2-hydroxybenzoic acid (189283-52-1)

Guidance literature:

With sulfuryl dichloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 24h;

Reference yield: 92.1%

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 5-chloro-2,4-difluorobenzoic acid → 5-chloro-4-fluoro-2-hydroxybenzoic acid (189283-52-1)

Guidance literature:

With sodium hydroxide;

Reference yield:

5-chloro-2,4-difluorobenzoic acid → 5-chloro-4-fluoro-2-hydroxybenzoic acid (189283-52-1) + 5-chloro-2-fluoro-4-hydroxy-benzoic acid (593280-19-4)

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide; at 130 ℃; for 3h; Further Variations:; Reagents; Temperatures; time; Product distribution;

DOI:10.1016/S0022-1139(02)00342-1

upstream raw materials:

4-fluorosalicylic acid

1-methyl-pyrrolidin-2-one

Downstream raw materials:

C₉H₆ClFO₄

(5-Chloro-4-fluoro-2-methoxymethoxy-phenyl)-(3-methoxymethoxy-pyridin-2-yl)-acetonitrile

2-Chloro-5-methoxymethoxy-4-(3-methoxymethoxy-pyridine-2-carbonyl)-benzonitrile

2-(5-chloro-4-fluoro-2-methoxymethoxybenzoyl)-3-methoxymethoxypyridine

Refernces

• 1、 Umezu, Kazuto,Tabuchi, Fumiya,Kimura, Yoshikazu. "Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives". . p. 97 - 99. Retrieved 2007/10/03.