(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

Base Information

Chemical Name:(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester
CAS No.:197172-43-3
Molecular Formula:C₂₆H₄₃NO₄Si
Molecular Weight:461.717
Hs Code.:

Synonyms:(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

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Chemical Property of (S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

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Technology Process of (S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

There total 10 articles about (S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 130317-28-1
benzyl 2R-trifluoromethanesulfonyloxy-4-methylvalerate

: 197172-40-0
(3S,4S)-4-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-3-hydroxy-azetidin-2-one

: 197172-43-3
(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -45 - 20 ℃;
DOI:10.1016/S0040-4039(98)01241-6

Reference yield:

: 20312-37-2,498-36-2
(R)-2-hydroxy-4-methylpentanoic acid

: 197172-43-3
(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃

2: 2,6-lutidine / CH₂Cl₂ / 0 °C

3: 44 percent / NaHMDS / tetrahydrofuran / -45 - 20 °C

With 2,6-dimethylpyridine; sodium hexamethyldisilazane; caesium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)01241-6

Reference yield:

: 328-38-1,21675-61-6,25248-98-0,70-45-1
(R)-leucine

: 197172-43-3
(S)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaNO₂, H₃O⁽¹⁺⁾

2: Cs₂CO₃

3: 2,6-lutidine / CH₂Cl₂ / 0 °C

4: 44 percent / NaHMDS / tetrahydrofuran / -45 - 20 °C

With 2,6-dimethylpyridine; oxonium; sodium hexamethyldisilazane; caesium carbonate; sodium nitrite; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(98)01241-6