ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Base Information

• Chemical Name: ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate
• CAS No.: 165808-07-1
• Molecular Formula: C₂₅H₂₄N₂O₅S₂
• Molecular Weight: 496.608

Synonyms:ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Chemical Property of ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Chemical Property:

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Technology Process of ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

There total 10 articles about ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1N-hydrochloric acid + 1-chloromethyl-2-methylsulfanylbenzene (26190-68-1) + ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165807-52-3) → ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165808-07-1)

Guidance literature:

With acetic anhydride; potassium carbonate; In pyridine; N-methyl-acetamide; methanol (18 ml)-tetrahydrofuran; water;

Reference yield: 78.0%

ethyl 6-(4-acetoxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165808-27-5) → ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165808-07-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; for 0.666667h; Ambient temperature;

DOI:10.1248/cpb.46.1724

Reference yield: 78.0%

→ ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165807-52-3) + ethyl 6-(4-hydroxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165808-07-1)

Guidance literature:

upstream raw materials:

ethyl 6-(4-acetoxyphenyl)-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

4-methoxybenzyl methyl ketone

1-chloromethyl-2-methylsulfanylbenzene

2-amino-4-methyl-5-(4-methoxyphenyl)thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

ethyl 6-(4-methoxymethoxyphenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydro<2,3-d>pyrimidine-3-acetate

[5-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-6-(4-methoxymethoxy-phenyl)-1-(2-methylsulfanyl-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

[6-(4-methoxymethoxy-phenyl)-1-(2-methylsulfanyl-benzyl)-2,4-dioxo-5-(pentanoylamino-methyl)-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

[5-(benzoylamino-methyl)-6-(4-methoxymethoxy-phenyl)-1-(2-methylsulfanyl-benzyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

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