N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

Base Information

Chemical Name:N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt
CAS No.:1311288-50-2
Molecular Formula:C₂HF₃O₂*C₂₀H₂₁N₃O₈
Molecular Weight:545.426
Hs Code.:

Synonyms:N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

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Chemical Property of N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

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Technology Process of N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

There total 11 articles about N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₃N₃O₈

: 76-05-1
trifluoroacetic acid

: 1311288-50-2
N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

Guidance literature:: C₃₄H₃₃N₃O₈; With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 13529-17-4
5-Formyl-2-furancarboxylic acid

: 1311288-50-2
N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: hexane; acetone / 0.17 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

4.1: CHIRALCEL OD / Resolution of racemate

5.1: lithium hydroxide / ethanol; water / 2 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C

7.1: water / 2 h / 20 °C

8.1: thionyl chloride / 0.33 h / 70 °C

9.1: pyridine / dichloromethane / 2 h / 20 °C

10.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

With pyridine; thionyl chloride; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; ethanol; hexane; dichloromethane; water; acetone;

Reference yield:

: 5904-71-2
methyl 5-formylfuran-2-carboxylate

: 1311288-50-2
N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: CHIRALCEL OD / Resolution of racemate

4.1: lithium hydroxide / ethanol; water / 2 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 20 °C

6.1: water / 2 h / 20 °C

7.1: thionyl chloride / 0.33 h / 70 °C

8.1: pyridine / dichloromethane / 2 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

With pyridine; thionyl chloride; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water;