5904-71-2

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 5-FORMYL-2-FUROATE is used as an intermediate in the synthesis of pharmaceutical compounds for its versatile chemical properties, contributing to the development of new drugs with potential therapeutic applications.
Used in Fragrance Industry:
METHYL 5-FORMYL-2-FUROATE is used as a fragrance ingredient for its distinct fruity odor, enhancing the scent profiles of various perfumes, cosmetics, and other fragranced products.
Used in Natural Products:
METHYL 5-FORMYL-2-FUROATE is found in some natural products, where it contributes to their unique characteristics and potential biological activities, such as antifungal and antimicrobial properties.
It is crucial to handle and store METHYL 5-FORMYL-2-FUROATE safely to prevent any potential hazards, given its chemical nature and applications across various industries.

InChI:InChI=1/C7H6O4/c1-10-7(9)6-3-2-5(4-8)11-6/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 1917-64-2 5-(methoxymethyl)-2-furaldehyde 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 75-91-2 tert.-butylhydroperoxide 

Downstream Products

• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 4282-32-0 furan-2,5-dicarboxylic acid dimethyl ester 
• 1311290-73-9 C₁₆H₁₃ClN₂O₄ 
• 1311287-81-6 N-{(2E)-3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropenoyl}-N-(3-hydroxypropyl)-β-alanine trifluoroacetic acid salt 
• 1311289-10-7 S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid trifluoroacetic acid salt 
• 1311287-84-9 N-{(2E)-3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropenyl}-L-glutamic acid trifluoroacetic acid salt 
• 1311289-12-9 (N'-carboxymethyl-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropane}hydrazido)acetic acid trifluoroacetic acid salt 
• 1311291-19-6 S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt 
• 1311289-08-3 O-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}-D-malic acid trifluoroacetic acid salt 

Relevant academic research and scientific papers

Ultrafine Copper Oxide Particles Dispersed on Nitrogen-Doped Hollow Carbon Nanospheres for Oxidative Esterification of Biomass-Derived 5-Hydroxymethylfurfural

One-pot synthesis of furan-2,5-dimethylcarboxylate (FDMC) from 5-hydroxymethylfurfural (HMF) is highly demanding for the commercial production of polyethylene furanoate (PEF). Herein, a direct synthesis of FDMC is reported from oxidative esterification of HMF using ultrafine CuO particles dispersed on nitrogen-doped hollow carbon nanospheres (CuO/N?C?HNSs) as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidizing and methylating reagent. The CuO/N?C?HNSs was prepared through a template protection-sacrifice strategy using SiO2 as a sacrificial template and histidine as the precursor for N and C. N-doping facilitated a strong interaction between the support and copper species, affording formation of CuO nanoparticles of less than 10 nm in size. By virtue of the highly dispersed CuO nanoparticles and a high BET surface area 373 m2/g, the CuO/N?C?HNSsshows excellent catalytic performance in the selective conversion of HMF into FDMC affording 93 % yield of the desired product with a TON value of 49. Furthermore, the oxidative esterification involving SP3C?H bond functionalization is also demonstrated using the same catalyst.

Method for preparing 5 - by catalyzing 2-hydroxymethylfurfural oxidation esterification and 5 -furandicarboxylic acid dimethyl ester (by machine translation)

To the method, 5 - hydroxymethyl furfural is contacted with a transition metal catalyst under the condition of an oxidizing atmosphere, and 2 5 - 5 - 2 5 - furandicarboxylic acid dimethyl ester is obtained. To the method, 5 - hydroxymethyl furfural is efficiently and selectively catalytically oxidized and esterified to 2 and 5 - furandicarboxylic acid dimethyl ester without an alkali additive. (by machine translation)

Oxidative Esterification of 5-Hydroxymethylfurfural under Flow Conditions Using a Bimetallic Co/Ru Catalyst

Furanic di-carboxylate derivatives of 5-Hydroxymethylfurfural (HMF) are nowadays important in the polymer industry as they are used as building blocks for bio-based polyesters. The high reactivity of HMF compels to avoid harsh synthetic conditions. Therefore, developing mild catalytic processes for its selective oxidation is a challenging task. Herein, we report the first oxidative esterification of HMF to dimethyl furan-2,5-dicarboxylate (FDCM) under flow conditions using oxygen as oxidant. For that purpose, a new series of nitrogen-doped carbon-supported bimetallic Co/Ru heterogeneous catalysts were prepared and characterized by XRD, XPS and N2 physisorption. These analyses revealed that the porosity of the materials and order of impregnation of the metals to the carbon supports lead to varying catalytic activities. Under optimized conditions the flow reactor showed a 15-fold increase on the production of FDCM compared to batch conditions.

Aerobic oxidative esterification of 5-hydroxymethylfurfural to dimethyl furan-2,5-dicarboxylate by using homogeneous and heterogeneous PdCoBi/C catalysts under atmospheric oxygen

The conversion of platform molecule 5-hydroxymethylfurfural (HMF) into many value-added derivatives has attracted significant interest. FDCA and its esters are important derivatives of HMF, which can be used as polyester monomers and pharmaceutical intermediates. In this paper, oxidative esterification of 5-HMF has been carried out by using homogeneous and heterogeneous PdCoBi/C catalysts under atmospheric oxygen. The effect of reaction conditions on product distribution has been studied under both homogeneous and heterogeneous catalytic conditions. The highest yields of oxidative esterification products are obtained at 93% and 96% by using homogeneous and heterogeneous PdCoBi/C catalysts, respectively. The catalysts are characterized by X-ray photoelectron spectroscopy (XPS) and powder X-ray diffraction (XRD). The catalytic system has better compatibility according to the expansion of the substrate. A reaction mechanism is proposed, and recycle experiments are also conducted.

PROCESS FOR PURIFYING AN ACID COMPOSITION COMPRISING 2-FORMYL-FURAN-5-CARBOXYLIC ACID AND 2,5-FURANDICARBOXYLIC ACID

An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid composition with an alcohol to obtain an esterified composition; and separating the ester of 2-formyl-furan-5-carboxylic acid from the esterified composition to obtain a purified esterified product; and contacting the purified esterified composition with water for saponification or hydrolysis, to obtain a product composition, comprising 2,5-furandicarboxylic acid and a reduced amount of 2-formyl-furan-5-carboxylic acid.