5904-71-2

Basic information

• Product Name: METHYL 5-FORMYL-2-FUROATE
• Synonyms: Methyl 2-formyl-5-furancarboxylate;Methyl 5-formyl-2-furancarboxylate;methyl 5-formylfuran-2-carboxylate;2-Furancarboxylic acid, 5-forMyl-, Methyl ester;5-(Methoxycarbonyl)-2-furancarboxaldehyde;5-(Methoxycarbonyl)furfural;5-Carbomethoxy-2-furaldehyde;5-Formyl-2-furancarboxylic acid methyl ester
• CAS NO: 5904-71-2
• Molecular Formula: C₇H₆O₄
• Molecular Weight: 154.12
• Mol File: 5904-71-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 87-88℃
• Boiling Point: 268℃
• Flash Point: 116℃
• Appearance: /
• Density: 1.265
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: METHYL 5-FORMYL-2-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-FORMYL-2-FUROATE(5904-71-2)
• EPA Substance Registry System: METHYL 5-FORMYL-2-FUROATE(5904-71-2)

Safety Data

• Hazardous Substances Data: 5904-71-2(Hazardous Substances Data)

Usage

General Description

Methyl 5-formyl-2-furoate is a chemical compound with the molecular formula C7H6O4. It is a furoate ester, which is a derivative of furoic acid. METHYL 5-FORMYL-2-FUROATE is commonly used in the synthesis of various organic compounds, particularly in the pharmaceutical and fragrance industries. It is also found in some natural products and has been associated with potential biological activities, such as antifungal and antimicrobial properties. Methyl 5-formyl-2-furoate has a fruity odor and is considered to be relatively stable under normal conditions. It is important to handle and store this chemical in a safe manner to prevent any potential hazards.

InChI:InChI=1/C7H6O4/c1-10-7(9)6-3-2-5(4-8)11-6/h2-4H,1H3

Upstream product

• 75-91-2 tert.-butylhydroperoxide 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 67-56-1 methanol 
• 1917-64-2 5-(methoxymethyl)-2-furaldehyde 

Downstream Products

• 4282-32-0 furan-2,5-dicarboxylic acid dimethyl ester 
• 1311290-73-9 C₁₆H₁₃ClN₂O₄ 
• 1311287-81-6 N-{(2E)-3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropenoyl}-N-(3-hydroxypropyl)-β-alanine trifluoroacetic acid salt 
• 1311289-10-7 S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid trifluoroacetic acid salt 
• 1311287-84-9 N-{(2E)-3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropenyl}-L-glutamic acid trifluoroacetic acid salt 
• 1311289-12-9 (N'-carboxymethyl-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropane}hydrazido)acetic acid trifluoroacetic acid salt 
• 1311291-19-6 S-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}thiomalic acid diethyl ester trifluoroacetic acid salt 
• 1311289-08-3 O-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropionyl}-D-malic acid trifluoroacetic acid salt 
• 1311288-62-6 N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2-methylpropanoyl}nipecotic acid trifluoroacetic acid salt 
• 1311288-52-4 5-{2-methyl-2-[(2-phenylethyl)carbamoyl]ethyl}furan-2-carboxylic acid 4-amidinophenyl ester trifluoroacetic acid salt 
• 1311288-50-2 N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-D-aspartic acid trifluoroacetic acid salt 
• 1311288-46-6 N-{3-[5-(4-amidinophenoxycarbonyl)furan-2-yl]-2R-methylpropionyl}-L-aspartic acid trifluoroacetic acid salt 

Relevant articles and documents

Ultrafine Copper Oxide Particles Dispersed on Nitrogen-Doped Hollow Carbon Nanospheres for Oxidative Esterification of Biomass-Derived 5-Hydroxymethylfurfural

One-pot synthesis of furan-2,5-dimethylcarboxylate (FDMC) from 5-hydroxymethylfurfural (HMF) is highly demanding for the commercial production of polyethylene furanoate (PEF). Herein, a direct synthesis of FDMC is reported from oxidative esterification of HMF using ultrafine CuO particles dispersed on nitrogen-doped hollow carbon nanospheres (CuO/N?C?HNSs) as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidizing and methylating reagent. The CuO/N?C?HNSs was prepared through a template protection-sacrifice strategy using SiO2 as a sacrificial template and histidine as the precursor for N and C. N-doping facilitated a strong interaction between the support and copper species, affording formation of CuO nanoparticles of less than 10 nm in size. By virtue of the highly dispersed CuO nanoparticles and a high BET surface area 373 m2/g, the CuO/N?C?HNSsshows excellent catalytic performance in the selective conversion of HMF into FDMC affording 93 % yield of the desired product with a TON value of 49. Furthermore, the oxidative esterification involving SP3C?H bond functionalization is also demonstrated using the same catalyst.

Oxidative Esterification of 5-Hydroxymethylfurfural under Flow Conditions Using a Bimetallic Co/Ru Catalyst

Furanic di-carboxylate derivatives of 5-Hydroxymethylfurfural (HMF) are nowadays important in the polymer industry as they are used as building blocks for bio-based polyesters. The high reactivity of HMF compels to avoid harsh synthetic conditions. Therefore, developing mild catalytic processes for its selective oxidation is a challenging task. Herein, we report the first oxidative esterification of HMF to dimethyl furan-2,5-dicarboxylate (FDCM) under flow conditions using oxygen as oxidant. For that purpose, a new series of nitrogen-doped carbon-supported bimetallic Co/Ru heterogeneous catalysts were prepared and characterized by XRD, XPS and N2 physisorption. These analyses revealed that the porosity of the materials and order of impregnation of the metals to the carbon supports lead to varying catalytic activities. Under optimized conditions the flow reactor showed a 15-fold increase on the production of FDCM compared to batch conditions.

PROCESS FOR PURIFYING AN ACID COMPOSITION COMPRISING 2-FORMYL-FURAN-5-CARBOXYLIC ACID AND 2,5-FURANDICARBOXYLIC ACID

An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid composition with an alcohol to obtain an esterified composition; and separating the ester of 2-formyl-furan-5-carboxylic acid from the esterified composition to obtain a purified esterified product; and contacting the purified esterified composition with water for saponification or hydrolysis, to obtain a product composition, comprising 2,5-furandicarboxylic acid and a reduced amount of 2-formyl-furan-5-carboxylic acid.