N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester
• CAS No.: 122900-14-5
• Molecular Formula: C₄₀H₅₀N₄O₁₁
• Molecular Weight: 762.857
• Mol file: 122900-14-5.mol

Synonyms:N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester

Chemical Property of N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester

There total 3 articles about N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-Tyr-Gly-OMe (7733-20-2) → N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester (122900-14-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / Na₂CO₃ / acetone / 8 h / Heating

2: H₂ / 10percent Pd/C / methanol

3: 1.) N,N'-carbonyldiimidazole / 1.) CH₂Cl₂, -15 deg C, 3 h, 2.) 4 deg C, 20 h

With hydrogen; sodium carbonate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; acetone;

DOI:10.1021/jm00163a044

Reference yield:

N-(tert-butoxycarbonyl)-O-<(bezyloxycarbonyl)methyl>-L-tyrosylglycine methyl ester (122900-05-4) → N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester (122900-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol

2: 1.) N,N'-carbonyldiimidazole / 1.) CH₂Cl₂, -15 deg C, 3 h, 2.) 4 deg C, 20 h

With hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00163a044

Reference yield:

N-(tert-butyloxycarbonyl)-O-(carboxymethyl)-L-tyrosylglycine methyl ester (122900-08-7) + Nε-carbobenzoxy-L-lysine benzyl ester hydrochloride (6366-70-7) → N-(tert-butyloxycarbonyl)-O-<<<<1-(benzyloxycarbonyl)-5-(carbobenzoxyamino)pentyl>amino>carbonyl>methyl>-L-tyrosylglycine methyl ester (122900-14-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; Multistep reaction; 1.) CH₂Cl₂, -15 deg C, 3 h, 2.) 4 deg C, 20 h;

DOI:10.1021/jm00163a044

upstream raw materials:

N-(tert-butyloxycarbonyl)-O-(carboxymethyl)-L-tyrosylglycine methyl ester

N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride

Boc-L-Tyr-Gly-OMe

N-(tert-butoxycarbonyl)-O-<(bezyloxycarbonyl)methyl>-L-tyrosylglycine methyl ester