7733-20-2

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 16944-14-2 Boc-Tyr-OH*DCHA 
• 3978-80-1 Boc-Tyr-OH 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 58822-25-6 Leu-enkephalin 
• 58569-55-4 met-enkephalin 
• 77427-00-0 Boc-Tyr-Gly-Gly-Phe-Leu-OBu^t 
• 75903-26-3 Boc-Tyr-Gly-N₃ 
• 82362-16-1 Boc-Tyr-Gly-Gly-Phe-Met-OBu^t 
• 112900-76-2 cyclo-(glycyl-t-tyrosyl) 4,4-dimethylallyl ether 
• 5845-66-9 3-(S)-(4-hydroxy-benzyl)-piperazine-2,5-dione 
• 23234-32-4 N-Boc-Tyr(Bn)-Gly-OMe 
• 75975-40-5 cyclo-Leu⁵-Enkephalin 
• 80727-54-4 Boc-Gly-Phe-Met-Tyr-Gly-N₂H₃ 
• 80727-53-3 Boc-Gly-Phe-Leu-Tyr-Gly-N₂H₃ 
• 80727-52-2 Boc-Gly-Phe-Met-Tyr-Gly-OMe 
• 77591-04-9 Boc-Gly-Phe-Leu-Tyr-Gly-OMe 
• 80727-49-7 cyclo-Met⁵-Enkephalin 

Relevant academic research and scientific papers

Structure-Activity Relationships of cyclo(l -Tyrosyl- l -tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct

A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium tuberculosis enzyme CYP121, have been synthesized and analyzed by UV-vis and electron paramagnetic resonance spectroscopy and by X-ray crystallography. The introduction of iodine substituents onto cyclo(l-tyrosyl-l-tyrosine) results in sub-μM binding affinity for the CYP121 enzyme and a complete shift to the high-spin state of the heme FeIII. The introduction of halogens that are able to interact with heme groups is thus a feasible approach to the development of next-generation, tight binding inhibitors of the CYP121 enzyme, in the search for novel antitubercular compounds.

Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines

Three naturally occurring oxyprenylated diketopiperazines were synthesized and preliminarily tested as growth inhibitory agents in vitro against various cancer cell lines. The compounds were tested on six human cancer cell lines with different sensitivity to proapoptotic stimuli using the MTT colorimetric assay. The data revealed that of the chemicals under study only deoxymicelianamide (11) displayed the highest activity, recording mean IC50 growth inhibitory values ranging from 2 to 23 μM. A comparative study with the non-geranylated saturated derivative of (11) revealed the importance of the presence of the geranyloxy side chain and the exocyclic 2,5-DPK double bond moiety for the observed activity.

Helical pores self-assembled from homochiral dendritic dipeptides based on L-Tyr and nonpolar α-amino acids

The synthesis of dendritic dipeptides (4-3,4-3,5)12G2-CH 2-Boc-L-Tyr-X-OMe where X = Gly, L-Val, L-Leu, L-lle, L-Phe, and L-Pro is reported. Their self-assembly in bulk and in solution and the structural and retrostructural analysis of their pe

Immobilized Aspergillus Oryzae Protease Catalyzed Formation of Peptide Bonds in Organic Solvent

Immobilized Aspergillus oryzae protease (AOP) catalyzed the formation of peptide bonds between N-protected amino acids and amino acid esters or amides in ethyl acetate. The influences of pH and reaction time on the coupling of Boc-L-Tyr and Gly-NH2/

A New Micelle-forming Peptide

A new micelle-forming peptide TFA*Tyr-Gly-Phe-Ala-OBz (TFA = trifluoroacetic acid) is synthesized and evidence for its micelle formation obtained from UV-VIS, fluorescence spectroscopy, conductomery and pH techniques; the critical micelle concentration (c