5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Base Information

Chemical Name:5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide
CAS No.:1354818-79-3
Molecular Formula:C₂₀H₁₀ClF₅N₄O₃S₂
Molecular Weight:548.901
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Suppliers and Price of 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

There total 4 articles about 5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235407-46-1
5-fluoro-2-(pyridazin-4-yl)-4-(trifluoromethyl)phenol

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: 1354818-79-3
5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 75 ℃; for 24h;

Reference yield:

: 445303-67-3
2-(3-fluoro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1354818-79-3
5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: Oxone / water; acetone / 0.25 h

2: iodine; silver trifluoroacetate / chloroform / 1 h

3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 45 °C / Inert atmosphere

4: potassium carbonate / dimethyl sulfoxide / 24 h / 75 °C

With Oxone; copper(l) iodide; iodine; silver trifluoroacetate; potassium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 219581-07-4
3-fluoro-4-(trifluoromethyl)phenol

: 1354818-79-3
5-chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; silver trifluoroacetate / chloroform / 1 h

2: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 45 °C / Inert atmosphere

3: potassium carbonate / dimethyl sulfoxide / 24 h / 75 °C

With copper(l) iodide; iodine; silver trifluoroacetate; potassium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;