tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Base Information

Chemical Name:tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate
CAS No.:1235406-85-5
Molecular Formula:C₁₄H₁₃ClF₂N₂O₄S₂
Molecular Weight:410.85
Hs Code.:
Mol file:1235406-85-5.mol

Synonyms:tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

Suppliers and Price of tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl (5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 97%
1g
$ 1110.00

Matrix Scientific
tert-Butyl (5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 97%
5g
$ 1666.00

Crysdot
tert-butyl(5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 95%
5g
$ 1665.00

Crysdot
tert-butyl(5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 95%
1g
$ 595.00

Crysdot
tert-butyl(5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 95%
250mg
$ 330.00

Total 6 raw suppliers

Chemical Property of tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Chemical Property:

Boiling Point:491.5±55.0 °C(Predicted)
PKA:-0.37±0.10(Predicted)
Density:1.523±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl (5-chloro-2,4-difluorophenyl)sulfonyl(thiazol-4-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

There total 1 articles about tert-Butyl[(5-chloro-2,4-difluorophenyl)sulfonyl]1,3-thiazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1235406-42-4
thiazol-4-ylaminocarboxylic acid tert-butyl ester

: 13656-57-0
5-chloro-2,4-difluorobenzene-1-sulfonyl chloride

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

Guidance literature:: thiazol-4-ylaminocarboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 5 ℃; for 0.5h;

5-chloro-2,4-difluorobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 12h;

Reference yield: 100.0%

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: C₉H₈ClN₃O

: C₂₃H₂₀Cl₂FN₅O₅S₂

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 18h; Inert atmosphere;

Reference yield: 100.0%

: 1174020-42-8,955029-44-4
(-)-(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: 76-05-1
trifluoroacetic acid

: 5-chloro-2-fluoro-4-(((3R,4S)-3-fluoropiperidin-4-yl)oxy)-N-(thiazol-4-yl)benzenesulfonamide 2,2,2-trifluoroacetate

Guidance literature:: (-)-(3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;