3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

Base Information

Chemical Name:3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin
CAS No.:893565-92-9
Molecular Formula:C₄₉H₇₁N₃O₁₁
Molecular Weight:878.116
Hs Code.:

Synonyms:3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

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Chemical Property of 3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

Chemical Property:

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Technology Process of 3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

There total 7 articles about 3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 893565-91-8
C₅₉H₈₇N₃O₁₅

: 893565-92-9
3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

Guidance literature:: With hydrogenchloride; In water; at 38 ℃; pH=2; Large scale reaction;
DOI:10.1021/op300064b

Reference yield:

: 18621-17-5
1-(diphenylmethyl)-3-hydroxyazetidine

: 893565-92-9
3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 0.25 h / -5 - 5 °C

2: ammonium hydroxide / water; isopropyl alcohol / 3 h / 70 - 75 °C / 2068.65 - 2585.81 Torr

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 50 °C / Large scale reaction

4: hydrogenchloride / water / 38 °C / pH 2 / Large scale reaction

With hydrogenchloride; ammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In water; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300064b

Reference yield:

: 33301-41-6
1-benzhydryl-3-azetidinyl methanesulfonate

: 893565-92-9
3-descladinosyl-11,12-dideoxy-6-O-methyl-12,11-(oxycarbonyl-(1-benzhydryl-azetidin-3-yl)-imino)-erythromycin

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / water; isopropyl alcohol / 3 h / 70 - 75 °C / 2068.65 - 2585.81 Torr

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 50 °C / Large scale reaction

3: hydrogenchloride / water / 38 °C / pH 2 / Large scale reaction

With hydrogenchloride; ammonium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; isopropyl alcohol; acetonitrile;
DOI:10.1021/op300064b