methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

Base Information

Chemical Name:methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate
CAS No.:912337-59-8
Molecular Formula:C₂₁H₂₄FN₃O₅S
Molecular Weight:449.503
Hs Code.:

Synonyms:methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

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Chemical Property of methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

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Technology Process of methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

There total 2 articles about methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912337-58-7
3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid

: 69282-28-6
potassium monomethyl malonate

: 912337-59-8
methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

Guidance literature:: 3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(2E)-propenoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 25 - 29 ℃; for 2.08333h;

potassium monomethyl malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; at 25 - 35 ℃; for 26h; Product distribution / selectivity;

Reference yield:

: (2E)-3-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-2-propenoyl chloride

: 69282-28-6
potassium monomethyl malonate

: 912337-59-8
methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

Guidance literature:: potassium monomethyl malonate; With triethylamine; magnesium chloride; at 25 - 28 ℃; for 2h;

(2E)-3-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-2-propenoyl chloride; In tetrahydrofuran; at 30 - 35 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 912337-59-8
methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate

: 912337-60-1
methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-4-pentenoate

Guidance literature:: methyl (4E)-5-{4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-oxo-4-pentenoate; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -65 ℃; for 1 - 2h;

With methanol; acetic acid; In tetrahydrofuran; methanol; water; ethyl acetate; for 0.0833333h;