N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine

Base Information

• Chemical Name: N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine
• CAS No.: 117499-10-2
• Molecular Formula: C₁₇H₂₃N₃O₈
• Molecular Weight: 397.385
• Mol file: 117499-10-2.mol

Synonyms:N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine

Chemical Property of N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine

There total 6 articles about N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-nitrophenyl)alanine (117499-15-7) → N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine (117499-10-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In formic acid; water; for 2h; under 1810.02 Torr; Yield given; Ambient temperature;

DOI:10.1021/jm00121a042

Reference yield:

2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one (711015-30-4) → N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine (117499-10-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / H₂O, AcOH / acetic acid / 0.25 h / 100 °C

2: 89 percent / 3 M HCl / 7 h / Heating

3: 23 percent / 1) NaBH₃CN, 2) conc.HCl / 1) MeOH, H₂O , pH = 6.0, r.t., 3 d, 2) 30 min

4: 45 percent / 7 M NaOH / H₂O / 24 h / 45 °C / pH = 10

5: H₂ / 10percent Pd/C / H₂O; formic acid / 2 h / 1810.02 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In formic acid; water; acetic acid;

DOI:10.1021/jm00121a042

Reference yield:

3-(4-nitrophenyl)-2-oxopropanoic acid (38335-24-9) → N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine (117499-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 23 percent / 1) NaBH₃CN, 2) conc.HCl / 1) MeOH, H₂O , pH = 6.0, r.t., 3 d, 2) 30 min

2: 45 percent / 7 M NaOH / H₂O / 24 h / 45 °C / pH = 10

3: H₂ / 10percent Pd/C / H₂O; formic acid / 2 h / 1810.02 Torr / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In formic acid; water;

DOI:10.1021/jm00121a042

upstream raw materials:

N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-nitrophenyl)alanine

2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one

3-(4-nitrophenyl)-2-oxopropanoic acid

(2E)-2-(acetylamino)-3-(4-nitrophenyl)prop-2-enoic acid

Downstream raw materials:

N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-isothiocyanatophenyl)alanine dihydrochloride