2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one

Base Information

• Chemical Name: 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one
• CAS No.: 711015-30-4
• Molecular Formula: C₁₁H₈N₂O₄
• Molecular Weight: 232.196
• Mol file: 711015-30-4.mol

Synonyms:2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one

Chemical Property of 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one

There total 3 articles about 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-nitrobenzaldehdye (555-16-8) + N-acetylglycine (543-24-8) → 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one (711015-30-4)

Guidance literature:

With sodium acetate; acetic anhydride; acetic acid; at 100 ℃; for 2h;

DOI:10.1021/jm00121a042

Reference yield:

(Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one (66949-13-1) → 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one (711015-30-4)

Guidance literature:

In acetonitrile; Irradiation;

DOI:10.1021/ol301741g

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 2-methyl-4-[(E)-(4-nitrophenyl)methylidene]-1,3-oxazol-5(4H)-one (711015-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / acetic anhydride / 100 - 110 °C

2: acetonitrile / Irradiation

With sodium acetate; In acetic anhydride; acetonitrile;

DOI:10.1016/j.tet.2013.09.009

upstream raw materials:

4-nitrobenzaldehdye

N-acetylglycine

(Z)-2-methyl-4-(4-nitrobenzylidene)oxazol-5(4H)-one

Downstream raw materials:

2-(Benzooxazol-2-ylsulfanyl)-N-{2-methyl-4-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-acetamide

2-(Benzothiazol-2-ylsulfanyl)-N-{2-methyl-4-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-5-oxo-4,5-dihydro-imidazol-1-yl}-acetamide

2-hydroxy-3-(4-nitrophenyl)-2-propenoic acid

N-(carboxymethyl)-N-(2-(bis(carboxymethyl)amino)ethyl)-3-(4-aminophenyl)alanine