3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Base Information

Chemical Name:3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one
CAS No.:215715-41-6
Molecular Formula:C₃₅H₃₇NO₈
Molecular Weight:599.681
Hs Code.:

Synonyms:3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

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Chemical Property of 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

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Technology Process of 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

There total 25 articles about 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 14-bromo-8,9-dihydro-3-isopropoxy-2,11,12-trimethoxy-6H-[1]benzopyrano[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 516465-82-0
(3-isopropoxy-4-methoxyphenyl)boronic acid

: 215715-41-6
3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; for 24h; Inert atmosphere; Sealed tube;
DOI:10.3987/COM-15-S(T)49

Reference yield: 42.0%

: 3-isopropoxy-4-methoxyphenyl 1-(3,4-dimethoxyphenethyl)-4-(3-isopropoxy-4-methoxyphenyl)-1H-pyrrole-2-carboxylate

: 215715-41-6
3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: With ISOPROPYLAMIDE; copper diacetate; palladium diacetate; potassium carbonate; at 100 ℃; for 36h; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.joc.9b01521

Reference yield:

: 621-59-0
isovanillin

: 215715-41-6
3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 95 percent / silver trifluoroacetate; iodine / CH₂Cl₂ / 12 h / Heating

3: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

4: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

5: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

6: 90 percent / DMAP; DCC / CH₂Cl₂; hexane / 5 h / 20 °C

7: CH₂Cl₂ / 21 h / 20 °C

8: 320.9 mg / N,N-diisopropylethylamine / CH₂Cl₂ / 30 h / Heating

With dmap; copper(l) iodide; ammonia; iodine; silver trifluoroacetate; potassium carbonate; potassium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00237-7