3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Base Information

• Chemical Name: 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
• CAS No.: 475232-32-7
• Molecular Formula: C₃₅H₃₅NO₈
• Molecular Weight: 597.665
• Mol file: 475232-32-7.mol

Synonyms:3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Chemical Property of 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 16 articles about 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)-7-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-8-methoxy-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one → 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (475232-32-7)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere;

DOI:10.3987/COM-16-S(S)63

Reference yield: 93.0%

3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one (215715-41-6) → 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (475232-32-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane; for 48h; Heating;

DOI:10.1016/S0968-0896(02)00237-7

Reference yield:

isovanillin (621-59-0) → 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (475232-32-7)

Guidance literature:

Multi-step reaction with 9 steps

1: 94 percent / K₂CO₃ / dimethylformamide / 48 h / 20 °C

2: 95 percent / silver trifluoroacetate; iodine / CH₂Cl₂ / 12 h / Heating

3: 66 percent / CuI; Et₃N / Pd(PPh₃)4 / 5 h / 45 °C

4: 89 percent / 3-chloroperoxybenzoic acid; KHCO₃ / CH₂Cl₂ / 1 h / 20 °C

5: 98 percent / NH₃ / methanol; CH₂Cl₂ / 2 h / 20 °C

6: 90 percent / DMAP; DCC / CH₂Cl₂; hexane / 5 h / 20 °C

7: CH₂Cl₂ / 21 h / 20 °C

8: 320.9 mg / N,N-diisopropylethylamine / CH₂Cl₂ / 30 h / Heating

9: 93 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / ethanol; CH₂Cl₂ / 48 h / Heating

With dmap; copper(l) iodide; ammonia; iodine; silver trifluoroacetate; potassium carbonate; potassium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(02)00237-7

upstream raw materials:

3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]-isoquinolin-6-one

isovanillin

O-isopropylisovanillin

2-iodo-5-isopropoxy-4-methoxybenzaldehyde

Downstream raw materials:

14-(3,4-dihydroxyphenyl)-2,3,11,12-tetrahydroxy-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one