(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

Base Information

Chemical Name:(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine
CAS No.:1207540-17-7
Molecular Formula:C₂₃H₂₇N₅O₂
Molecular Weight:405.5
Hs Code.:

Synonyms:(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

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Chemical Property of (morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

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Technology Process of (morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

There total 4 articles about (morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 140645-53-0
2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester

: 1207541-14-7
trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester

: 1207540-17-7
(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

Guidance literature:: 2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester; trifluoromethanesulphonic acid 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl ester; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2h;

With trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 3222-56-8
2-methylnicotinic acid

: 1207540-17-7
(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -65 - 0 °C / Inert atmosphere

1.2: -65 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

3.2: 20 °C

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

: 7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ol

: 1207540-17-7
(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2.2: 20 °C

With pyridine; In 1-methyl-pyrrolidin-2-one; dichloromethane;